Characterization of Dact1 role in neuromuscular junctions development

The formation of neuromuscular junctions (JNMs), structures essential for muscle contraction, intrinsically correlates with the Wnt/PCP signaling pathway. Dact1 is a critical regulator of the transmembrane protein Vangl2, central to Wnt/PCP signaling, which coordinates the formation of clusters of the neurotransmitter acetylcholine. Thus, it is plausible to hypothesize that Dact1 modulates the development of JNMs.