CHARACTERIZATION OF BETACORONAVIRUS INFECTION AN OBESE MURINE MODEL

SARS-CoV-2 is the causative agent of acute respiratory distress syndrome (ARDS). In recent years, SARS-CoV-2 has caused high levels of morbidity and mortality. Patients with comorbidities are a major risk of severe complications and deaths, including chronic diseases, such as: obesity and diabetes. Therefore, it is important to understand the pathological mechanisms and how obesity features may aggravate the disease. Here, we used a murine pneumotropic betacoronavirus (MHV-59) to induce ARDS-like infection in obese C57BL/6J mice.