CAFFEINE MODULATES CANNABINOID-INDUCED CONDITIONED PLACE PREFERENCE IN A RAT MODEL OF ATTENTIONAL-DEFICIT/HYPERACTIVITY DISORDER.

Attention-deficit/hyperactivity disorder (ADHD) is a complex neuropsychiatric disorder characterized by symptoms of hyperactivity/impulsivity and/or inattention and is often associated with comorbidities, including substance use disorders. Previous studies have shown that treatment with caffeine (a non-selective antagonist of A1 and A2A adenosine receptors) can improve ADHD-related behaviors in rodents.