ARIPIPRAZOLE PREVENTS THE EFFECTS OF NICOTINE ON CPP

Nicotine is a substance with high abuse potential that is able to modulate the mesocorticolimbic doparminergic pathway, also known as the reward system. Aripiprazole is a dopaminergic and serotonergic receptor partial agonist used in the treatment of schizophrenia and bipolar disorder. Recent studies have shown that aripiprazole can also act to attenuate the effects of drugs of abuse, as has been shown for alcohol and cocaine.