Antitumor Activity of copper (II) complexes with Schiff Bases derived from Cinnamaldehyde.

Metal complexes are interesting for the treatment of cancer due to the unique properties of metals, including the redox potential, several possible coordination structures with different types of ligands, the most diverse geometries, in addition to different reactivity with biomolecules. The discovery of cisplatin decades ago represented a significant advance in the search for cancer therapies. This made efforts to develop compounds with other structures and use other metallic centers. The present work seeks to synthesize new copper complexes with imine ligands using a natural aldehyde, cinnamaldehyde. A naturally occurring compound isolated from the bark of trees of the genus Cinnamomum sp.