Alterations in hippocampal-prefrontal cortex connectivity are associated with working memory impairments in rats subjected to early-life Status epilepticus

Status Epilepticus (SE) during childhood is associated with development of epilepsy and cognitive impairments. Experimental studies show that SE during early-life do not present the neuropathological findings associated with temporal lobe epilepsy (TLE). However, they describe behavioral alterations and memory impairments. Understanding how epileptogenic processes occur and compromise cognition throughout development is essential to guide clinical interventions. Therefore, we hypothesized that these deficits result from changes in hippocampal-cortical-thalamic connectivity, specifically in the synchrony of oscillatory field activity involving these neural circuits.