Alterations caused by obesity and overweight in Ca2+-ATPase and PKCα activity of erythrocyte membrane

Obesity has become a public health problem in the world. Overweight and obesity are correlated with several comorbidities, including hypertension, diabetes mellitus, heart disease, and cancer. The metabolic and hormonal changes that occur in obesity lead to changes in the hydroelectrolytic balance. In obesity, erythrocytes may show changes in intracellular calcium concentrations, this modification may reduce membrane fluidity, decrease cytoskeletal plasticity and reduce erythrocyte durability. Ca2+-ATPase is responsible for keeping intracellular calcium concentrations low.