AGING INDUCES NAD+ REDUCTION BUT NOT SIRT1/NRF2/ANTIOXIDANT PATHWAY.

According to the World health organization, people with age >60 years tend to increase to 1.4 billion by 2030 and 2.1 billion by 2050. There is some common disease which accompanies aging. As an example, diabetes, Systemic arterial hypertension, chronic inflammation and others. Some theories of aging could explain the consequences cited. For example, the redox homeostasis unbalance. The theory of unbalance in redox explains that with an increase in the production of reactive oxygen species (ROS) or a decrease in antioxidant capacity, an oxidative stress environment is created culminating with consequences as insulin resistance. As an example of unbalanced redox capacity, the reduction of oxidized nicotinamide (NAD+) could induce reduction of Glutathione antioxidant capacity. A lot of studies focus on the effect of ROS accumulation inducing metabolic consequences. But no one investigated this in aged adipose tissues and the adipose tissue is a relevant tissue for insulin sensitivity, thermogenesis, the control of food ingestion with endocrine properties and relevant for systemic inflammation.