Acute modulation of endocannabinoid CB1 and CB2 receptors on locomotor activity and risk-taking behavior of an ADHD animal model

Attention deficit/hyperactivity disorder (ADHD) is considered a neurodevelopmental disorder with a high prevalence that affects different age groups. Beyond the classical behavioral symptoms, ADHD is often associated with high-risk behaviors. ADHD’s neurobiology is complex, and it has been hypothesized as a dopamine (DA) hypofunction in the frontocorticostriatal circuit. The endocannabinoid system (ECS) plays a pivotal role in the modulation of inhibitory and excitatory synapses and its principal cannabinoid receptors (CBR) CB1 and CB2 are widely expressed in DA neurons.