Integrated analysis of microarray and proteomics data by embryonic hippocampal rat neurons and human neurons treated with different doses of lithium

Lithium salts have a well-established role in the treatment of psychiatric disorders, such as major affective disorders, and more recently Alzheimer disease. Experimental and clinical studies have provided evidence that lithium may exert neuroprotective effects at therapeutic and subtherapeutic doses. Objective: The aim of this study is to compare biological processes and pathways enriched in embryonic hippocampal neurons treated with different doses of lithium (0.02mM, 0.2mM and 2mM). Results: The results showed that growing gene networks using differentially expressed genes and proteins as seeds alterations in mitochondria, ribosome and proteasome were observed for all lithium treatment doses.