Applied of bacterial cellulose nanocrystals for stabilization of pickering-emulsion based systems for drug delivery

Nowadays, one technology applied on emulsions is about substitution of surfactant by micro or nanoparticles, which are able to fix in the interface of polar and nonpolar, contributing for the stability of the emulsion system, having many pharmacotechnics and biopharmaceuticals benefits. This work had applied bacterial cellulose nanocrystals (NCC) because of its renewable and sustainable origin, low price and good biocompatibility e biodegradability to stabilize emulsion based system. Therefore, the formulation used in the test was composed by castor oil, sorbitan monooleate (Span 80), poly (oxyethylene) sorbitan monooleate (Tween 80) and water. The sample was homogenized and dripped in a calcium chloride solution (2M). The microspheres were washed and put in contact with NCC. The material was frozen into -80ºC and lyophilized. The characterization by FTIR, DSC, DLS, zeta potential, optical microscopy and SEM were did. The results showed that the formulation presented had good physics-chemical characteristics, being considered a system for controlled release of drugs.