Sibutramine poisoning attended by toxicological information centers between 2017 and 2018

Background: Obesity is a serious public health problem that affects adults and children (1). Sibutramine is a monoamine reuptake inhibitor used in weight reduction (2) Aim: To describe cases of sibutramine poisoning. Methods: We accessed the intoxication reports available in Datatox 2017 and 2018 and performed a descriptive analysis with the following variables: gender, age group, exposure condition, associated agents, severity rating and symptoms. Results: There were 233 reports of sibutramine poisoning during this period and use in attempted suicide was prevalent. It was observed larger use in women adult (Table 1). Discussion: Use of sibutramine in suicide attempts was relevant in the female adult population, but the degree of intoxication was mild to moderate. There was a greater association with antidepressants and anxiolytics, and the symptoms sleepiness, tachycardia and nausea were more prevalent. Conclusion: Sibutramine poisoning is at low risk for serious events.