Mycocins activity against Candida albicans isolated from vulvovaginitis

Vulvovaginal candidiasis is an emerging disease in developing countries and is the second most common cause of vulvovaginitis. Mycocins are considered secondary metabolites of protein or glycoprotein nature, with antimicrobial activity because they cause disturbance in the pathogen cell wall like deleterious effect. These mycocins can be produced by the Wickerhamomyces anomalus yeast, which has several strains. Interest in mycocins as a new antimicrobial agent has been increasing due to the broad spectrum of fungal and bacterial infections, as numerous pathogens demonstrate resistance to conventional antibiotics. In this work the antimicrobial activity of WA40 mycocins was tested in solid medium with 100% inhibition of Candida albicans strains. The chorioallantoic membrane test was performed, used to evaluate the eye irritation of cosmetic products, where the mycocins were classified as slightly irritating, because they coagulated only after 2 minutes of contact with the membrane, being safe to be implemented in future formulations.