Encapsulation of Monoterpene Perillyl Alcohol in Solid Lipid Nanoparticles for Antitumor Evaluation

Cancer is a group of diseases characterized by uncontrolled growth of abnormal cells. (AMERICAN CANCER SOCIETY, 2015). In this context, the potential use of pharmaceutical nanotechnology in the development of nanocarrier systems is possible through the production and modification of physicochemical and biological properties using nanoscale materials, such as solid lipid nanoparticles (SLN), which aim to control release and targeting. bioactive, protection against chemical degradation and reduction of possible adverse effects (DANAEI et al., 2018). The results showed that SLN-AP has an average particle diameter around 254 nm, polydispersity index ~ 0.35, zeta potential ~ -14.7 and encapsulation efficiency around 92%. In addition, the results indicated that AP-loaded SLN showed tumor inhibition rate of treated animals and their respective controls. A significant reduction of 51.76 and 54.49% in tumor mass was observed in i.p. with NLS-AP at doses of 100 and 200 mg / kg / day (p <0.05) compared to negative control (DMSO 5%), respectively.