Effects of curcumin loaded polymeric nanoparticle on the organogenesis period in pregnant rats

There are few studies showing the safety of polymeric nanoparticles (NP) in pregnancy. Then, curcumin loaded polymeric nanoparticle (CNP) were developed through the nanoprecipitation method in order to evaluate their effects on the organogenesis period in rats, that received CNP, curcumin or saline by oral route from 7th to 13th gestational day (DG). Females were evaluated daily for weight evolution, water and food intake and clinical signs. In DG 20, they were sacrificed, and fetuses were evaluated for external malformations and their biometrics. There was no significant difference between groups regarding body weight gain, water and food intake of pregnant females. No external abnormalities and fetal developmental delays were observed in any of the treated groups. Then, in this protocol, we can observe that CNP may be an option for treatment in pregnant.