Determination of Parabens in Anti-inflammatory Medicines

Vol. 1, 2019. - 117983
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Parabens are preservatives used in medicines, but there is evidence that some parabens have activity as endocrine disruptors. A capillary electrophoresis method was optimized to quantify butyl (BP), propyl (PP), ethyl (EP) and methyl (MP) parabens in anti-inflammatories containing as active ingredient ketoprofen or
prednisolone. LOD and LOQ were estimated as 3 and 10 mg/L, respectively. Linearity was evaluated at a concentration range from 10 to 100 mg/L, and good coefficients of correlation (r > 0.99) were obtained for all parabens. Recovery was estimated by fortified samples prepared in three replicates at 10, 50 and 100 mg/L
of each paraben and values ranged from 95 to 106% for ketoprofen and from 86 to 118% for prednisolone medications. Precision (n=3) varied from 0.2 to 6.4% and 0,3 to 6.3 %, in ketoprofen and prednisolone medicines, respectively. This method will be used to quantify parabens in pediatric medicines aiming to assess exposure to these compounds.

  • 1 Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP), Universidade de São Paulo (USP)
  • Toxicology
capillary electrophoresis