Compatibility Study between Cannabidiol and Oils Commonly Used in Lipid Systems by Differential Scanning Calorimetry (DSC) and Thermogravimetry Analysis (TGA)

The purpose of this study was to evaluate the Cannabidiol (CBD) compatibility with oils commonly used as their carrier (olive oil, safflower oil, soy oil, sesame oil and Miglyol® 812N) in order to provide useful knowledge for the development of a lipid-based nanostructured product. Pure CBD and its binary mixtures (BM - 1:1(w/w)) with the oils were analyzed from 30 to 500°C under nitrogen atmosphere by TGA and DSC. The results revealed that CBD was soluble in all oils, since the DSC signal for its melting point (Tpeak 74.4 °C) disappeared in all BMs. The TGA of most oil samples showed similar behavior, due to their chemical composition, and were able to reduce CBD decomposition. However, Miglyol® 812N induced an early CBD degradation, a noteworthy incompatibility with a solvent/vehicle. Finally, the overall results allow us to suggest that olive, safflower, soy and sesame oil are suitable compounds for further evaluation as potencial lipofilic CBD carriers.