At the beginning, in 2001, we could not imagine that the Brazilian Symposium on Medicinal Chemistry (BrazMedChem) would become the largest scientific event exclusively dedicated to Medicinal Chemistry in Latin America. During the last twenty years all organizers excelled in the design of multidisciplinary scientific programs that cover the most diverse disciplines and areas that constitute the mosaic of Research in medicinal Chemistry and complex chain of drug discovery and development. The presence of thousands of young and senior researchers around the world have been the registered trade of BrazMedChem, ensuring a friendly interactive and collaborative atmosphere, aiming to discuss the state of the art of Medicinal Chemistry and how our work and perspectives can help science to overcome all current challenges related to collective health and effective advances in pharmaceutical sciences and drug discovery.