Evaluation of Methods to Encapsulate Chenopodium Ambrosioides L. Oily Extract Inside Lignin Nanocapsules

The present work aims to study the encapsulation of Chenopodium ambrosioides L. oily extract inside lignin nanocapsules. Due to the lignin biodegradability and biocompatibility, together with the medicinal properties of Chenopodium ambrosioides L., like in the treatment of cutaneous leishmaniasis (PATRÍCIO, 2008), this study focusses in the medical area. The encapsulation objective is to produce a gradually release, extending its the effect. During the development, two methods were evaluated, the one-pot synthesis of the nanocapsules by using an antisolvent with the oily extract, and the vacuum infiltration of hollow lignin nanocapsules (also obtained by antisolvent technique) with the oily extract. The produced lignin nanocrocapsules were characterized by thermal, spectroscopical, and morphological methods, to define the best synthesis parameters, encapsulation efficiency, degradation stability and release kinetics. It was observed that the one-pot synthesis presents the best efficiencies for the encapsulation of the oily extract of Chenopodium ambrosioides L. in lignin microcapsules.