Revisiting through multicomponent one-pot reaction and two steps the synthesis of a series of 10-aryldihydropyrano[2,3-f]chromenes

Fused heterocycles have attracted considerable interest because of their diverse biological activities and their importance as versatile scaffolds in organic synthesis¹. Among these, pyranocoumarins are particularly valuable as key intermediates for the synthesis of a wide range of biologically active compounds². As fused dihydropyran–chromene derivatives, pyranocoumarins exhibit numerous pharmacological properties, including anti-HIV, antitumor, anticancer, antibacterial, and anti-inflammatory activities³. Given the broad spectrum of biological activities associated with the pyranocoumarin framework, this study focuses on the synthesis of novel fused dihydropyran–pyranocoumarin derivatives through one-pot multicomponent reactions (MCRs). The synthesized compounds were characterized by high-resolution mass spectrometry (HRMS) and nuclear magnetic resonance (NMR) spectroscopy. Their biological potential will be investigated by evaluating their inhibitory activities against α-amylase and α-glucosidase, as well as their in vitro cytotoxicity against tumor cell lines and intracellular amastigotes of Leishmania amazonensis and Trypanosoma cruzi.