Exploring Zeo-click synthesis: Cu(I)-supported hierarchical zeolite-catalyzed synthesis of coumarin-1,2,3-triazoles.

The combination of coumarin and 1H-1,2,3-triazole scaffolds has emerged as a promising strategy for the development of bioactive compounds with diverse biological activities, motivating the synthesis of such hybrid structures through efficient and sustainable methodologies. Coumarin–triazole hybrids have been widely accessed via CuAAC due to their modularity and synthetic efficiency. Although CuAAC represents a major advance in organic synthesis, concerns regarding catalyst recovery, metal contamination, and waste generation have motivated the development of more sustainable protocols. In this context, heterogeneous catalytic systems based on zeolites offer advantages in terms of recyclability and reduced metal contamination, despite diffusion limitations mitigated by hierarchical porosity. Herein, Cu(I)-supported hierarchical zeolites were prepared and evaluated as catalysts for the synthesis of coumarin–1,2,3-triazole hybrids. Preliminary results indicate efficient catalytic activity, affording the desired products in good yields. The methodology is currently under optimization toward a reusable and efficient Zeo-Click protocol.