A simple and practical intramolecular cyclization employing potassium persulfate for the synthesis of 4-phenylselenyl-2H-chromenes

2H-Chromenes are versatile oxygen heterocycles represent an important scaffold in medicinal chemistry, exhibiting a broad spectrum of pharmacological activities such as anticoagulant, antitumor, and anti-inflammatory activities.¹ Despite their relevance, the synthesis of these bicyclic systems from terminal aryl propargyl ethers remains challenging,² typically requiring expensive gold catalysts or harsh reaction conditions.³   This work presents a simple and user-friendly methodology for the synthesis of novel functionalized 4-phenylselenyl-2H- chromenes via the intramolecular cyclization of terminal alkynes employing potassium persulfate as the oxidant. The protocol provides a metal-free alternative that overcomes the complexity of C-H bond activation inherent to these structures. The methodology afforded the regioselective formation of functionalized heterobicyclic systems under operationally simple conditions, with yields ranging from good to excellent (60 to 95%). This approach provides a practical tool for the rapid generation of compound libraries for drug discovery and other applications in materials science and agrochemical.