Synthesis, Characterization and Biological Evaluation of Novel Ru(II)-Benzimidazole Derivative Complexes

 In this work, four new ruthenium complexes containing phosphines and the molecule 2-mercaptobenzimidazole were obtained. Their structures were characterized by diverse techniques used in coordination chemistry, including 1D and 2D Nuclear Magnetic Resonance (NMR), cyclic voltammetry, mass spectrometry, and single-crystal X-ray diffraction. Their stability in DMSO was investigated by ³¹P{¹H} NMR. The interaction with human serum albumin (HSA) and DNA were evaluated to gain insights about the pharmacokinetics and pharmacodynamics of the compounds, respectively. One complex showed remarkable activity toward A549 cell line, being a hundred times more cytotoxic than cisplatin. In addition, it was able to induce changes in A549 cell morphology and inhibit cell migration. These results indicate promising candidates for the treatment of lung cancer.