Melatonin-Inspired N-Acylhydrazone Protects against ROS in vitro and Copper Stress in Saccaromyces cereviseae Cells

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Abstract

This study details the synthesis and evaluation of a novel N-acylhydrazone inspired by melatonin's neuroprotective properties. Designed to target the systemic metal imbalance and copper-induced oxidative stress in Alzheimer's disease, the compound successfully mitigated metal toxicity in early testing. Supported by favorable LogP, hydrolytic stability and molecular docking profiles, it emerges as a promising dual-action therapeutic candidate.

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Programme
19:40 to 21:00 on 09/15/2026
Room 4 and 5
Institutions
  • 1 Pontifical Catholic University of Rio de Janeiro
  • 2 Brazilian Center for Research in Physics
  • 3 Federal University of Rio de Janeiro (UFRJ)
  • 4 Federal University of Rio de Janeiro
  • 5 PUC-RIO
Track
  • TL03 - Biological and Medicinal Inorganic Chemistry
Keywords
Alzheimer's disease
Melatonin
N-acylhydrazone