A novel antimicrobial silver trans-cinnamate prototype against the resistance phenomenon

Antimicrobial resistance occurs when microorganisms develop mechanisms that reduce treatment efficacy, making infections harder to combat. In this context, silver compounds stand out as promising alternatives due to their broad-spectrum action and low propensity to induce resistance. This study aimed to synthesize and characterize a novel silver complex using *trans*-cinnamic acid as a ligand. This study aimed to synthesize and characterize a novel silver complex with potential antimicrobial activity, using trans-cinnamic acid as the ligand. Bactericidal assays demonstrated activity against *Staphylococcus aureus* and *Escherichia coli* at a Minimum Inhibitory Concentration (MIC) of 3.40 μg mL⁻¹, compared to the positive control, silver sulfadiazine (3.13 μg mL⁻¹). The results suggest that the silver complex shows potential as an antimicrobial agent, given that its antimicrobial activity is similar to that of the complex used in clinical practice.