The study of natural products as a healing agent has been intensifying. Poincianella pluviosa has already been described as a healing of skin wounds and in the formation of the collagen fiber1. Drug carrier systems such as cyclodextrins (CD) can modulate release kinetics and enhance absorption2. In an attempt to improve the release in the skin and, consequently, to obtain a better therapeutic response, the objective of this study was to evaluate the collagen fibers of skin wounds using crude extract (CE) of P. pluviosa complexed with CD. For the preparation of the CE were used stem bark collected in Maringá-PR. CE was complexed with hydroxypropyl-β-cyclodextrin in 1: 1 (w / w) and used in gel form (CECD gel) for the treatment of wounds. The base gel was used as negative control. The inclusion complex characterization was performed by infrared Fourier transform, photoacoustic spectroscopy and X-ray diffraction3. Were analyzed the CE, CD, complex CECD and simple mixture of CE and CD. For the in vivo experiments, 20 Wistar rats were divided into 4 groups (n = 5) according to the treatment period: 4, 7, 10 and 14 days. Two excisional wounds were done on the back and treated daily. One of the wounds received the CECD gel and the other, the negative control. In the end of each period, skin samples were submitted to histological analysis, stained by the Picrosírius technique to quantify the area occupied by type I (mature) and type III (immature) collagen fibers. The images were captured in optical microscope coupled to a polarizer, for differentiation of the collagen fibers. Fiber quantification was performed using the Image Pro-Plus® program and statistical data were obtained by GraphPad Prism® using t-test and Mann-Whitney. The complexation of CE with HPβCD was confirmed, suggesting its interaction with more nonpolar parts of the CE. Treatment of EBCD gel wounds showed predominance of type I fibers at all treatment periods and increased proliferation of type III fibers at 7 days of treatment, compared to the negative control. The complexation of part of the extract with cyclodextrin may have caused a change in the production of collagen in the dermis.