Chemical investigation and ecological role of Trichoderma spp. associated to different colonies of stingless bees

Strains of Trichoderma spp. were isolated from different colonies of the stingless bees Melipona marginata, Melipona quadrifasciata, and Frieseomelitta varia. Chemical dereplication based on HPLC-HRMS/MS data analysis of metabolic extracts from the microorganisms demonstrated the major production of pyrone derivatives, which were also stimulated during the microbial interaction of these isolates with commercial entomopathogenic fungi.