Chemical profile, antioxidant, antiproliferative and anti-inflammatory activity of Leandra aurea (Melastomataceae) flowers

Leandra aurea (Melastomataceae) flowers extract (CE) was evaluated for its chemical profile, antioxidant, antiproliferative (in vitro) and anti-inflammatory (in vivo) activities. HPLC profile shows CE contains ellagitannins, triterpenes and flavonoids. CE was active against DPPH and ABTS radicals and had ferrous chelating capacity. CE has strong antiproliferative activity against glioma and breast cells and moderate activity against NCI-H460 cells. CE inhibited 83.6% of myeloperoxidase enzyme.