Signaling molecules are used by microorganisms for the communication and synchronization of microbial behaviors in a mechanism described as quorum sensing (QS). These molecules are produced, secreted and detected by microorganisms and include N-Acyl homoserine lactones (AHL), among others. QS occurs through the binding of AHL with receptors of LuxR category, a transcriptional activator protein that activated the LuxI, a promotor protein, responsible for the gene expression. Considering the involvement of the QS with the pathogenicity and production of virulence factors it is necessary to search means to interrupt this mechanism through other biomolecules, in a process called quorum quenching (QQ). This research verified the QQ potential of the bacteria Marinobacter excellens LAMA 842. Overlay assays with the indicator bacteria Chromobacterium violaceum and Serratia marcescens were employed for the detection of QQ activity. Next, the QQ potential was quantified throughout the luminescence bacteria test with Aliivibrio fischeri, using the microbial culture supernatant with 48 and 72 hours. The growth curve was determined with 10 samples in an interval of 0 to 48 hours and evaluated in 600 nm wavelength. M. excellens LAMA 842 demonstrated an inhibition index of 4.27 (+/- 0.64) and 2.84 (+/- 0.33) on C. violaceum and S. marcescens respectively. Thirty percent bioluminescence inhibition was observed in 48 hours, while in 72 hours only 5% inhibition was detected. It reached the end of the exponential phase in less than 24 hours, with a generation time of two and half hours. Lastly, five Open Reading Frames (ORFs) related to the LuxR family were identified in its genome. Evidence of LuxI promoters was not found. Potential enzymes for the inactivation of QS were detected within 75 ORFs distributed among the peptide synthetase, lactonases (2), acylases (5) and oxidoreductase (67). While investigating the QS subcategory in the automatized Rapid Annotation using Subsystem Technology (RAST), it wasn’t possible to find annotation of metabolic pathways or functions related with it. As conclusions, it is possible to allege that M. excellens LAMA 842 has inhibitory potential for QS mechanism. However it is still necessary to elucidate the mode of action of the biomolecules produced by this bacterial strain.