Anais do Congresso Paranaense de Microbiologia
IV Congress of Microbiology in Paraná

Proteus mirabilis is a Gram-negative, rod-shaped bacterium, that belongs to the Enterobacteriaceae family, and it is known for inhabiting both soil and human gut microbiota, as well as in other mammal intestines. This microorganism is also frequently associated with the presence of virulence and resistance factors that allows the bacteria to install itself in many sites and cause infections, mainly opportunistic, on the skin, throat, eyes, and urinary tract, with the latter being the most prevalent. These facts highlight a strong need to study the characteristics of this pathogen, mainly those that permit its survival even in the presence of antibiotics. To achieve this better understanding, this study aimed to evaluate the antimicrobial resistance profile of P. mirabilis isolated from urine cultures belonging to the Laboratory of Bacteriology’s bacteriologic collection, and utilized antimicrobials of clinical and veterinary use. A total of 100 bacterial strains were analyzed, all of them were collected from Basic Health Units in all regions of the city of Londrina (North, South, East, West, Center), located in the North of Paraná. For the phenotypic resistance profile evaluation, 20 different antimicrobials were tested through the Vitek 2® system. After the analysis, we found that 8 (8%) were resistant to Amoxicillin-clavulanate, 38 (38%) to Ampicillin, 26 (26%) to Cephalexin, 4 (4%) to Cefoxitin, 10 (10%) to Ceftriaxone, 3 (3%) to Ceftazidime, 10 (10%) to Cefepime, 25 (25%) to Nalidixic acid, 15 (15%) to Ciprofloxacin, 14 (14%) to Norfloxacin, 25 (25%) to Enoxacin, 34 (34%) to Sulfamethoxazole-trimethoprim, 12 (12%) to Gentamicin, 21 (21%) to Chloramphenicol, 3 (3%) to Aztreonam, 12 (12%) to Tobramycin, 10 (10%) to Ceftiofur) and 6 (6%) to Phosphomycin. No isolate presented resistance to antimicrobials from the Carbapenems class or to Amikacin. Ampicillin showed the least effectiveness against the isolates, while Ceftadizime, Amikacin and Carbapenems were the most effective. With these results, we can conclude that community acquired urinary tract infections caused by P. mirabilis are worrisome, as the bacteria presented resistance not only to human use antimicrobials, but to animal use as well. This knowledge demonstrates a risk to the population and the need to utilize antimicrobials in a well thought and rational way, both in clinical and veterinary situations, in order to stop as much as possible the selection of multiresistant strains.