ANTIMICROBIAL SUSCEPTIBILITY PROFILE OF Proteus Mirabilis STRAINS ISOLATED FROM URINE OF BASIC HEALTH UNITS PATIENTS FROM THE MUNICIPALITY OF LONDRINA

Urinary tract infection (UTI) is one of the main infections acquired in the community and can be defined as microbial multiplication and tissue invasion of any part of the urinary tract (from the urethra to the kidneys). Proteus mirabilis is characterized as one of the bacterial species most involved in UTIs, especially in patients using a urinary catheter for a long period of time. This microorganism is capable of causing symptomatic infections (such as cystitis and pyelonephritis) and is present in asymptomatic cases of bacteriuria, in addition to being able to form urinary calculi. Over time, P. mirabilis has developed resistance to several classes of antibiotics, which presents a great difficulty in the treatment of UTIs by this microorganism. The objective of the present study was to evaluate the antimicrobial resistance profile in 175 P. mirabilis strains isolated from urinary infections of patients from several Basic Health Units (BHU) of Londrina - PR. To verify the antimicrobial resistance, the antibiogram was performed by the VITEK system and the antibiotics tested were: amikacin, amoxicillin + clavulanic acid, ampicillin, cephalothin, cefepime, ceftriaxone, cefuroxime, ciprofloxacin, ertapenem, gentamicin, meropenem, nitrofurantoin, norfloxacin, piperacillin + tazobactam, trimethoprim + sulfamethoxazole, nalidixic acid. Of all isolates tested, 130 (74.29%) were resistant only to the antibiotic Nitrofurantoin, 15 (8.57%) were resistant to one or more antibiotics besides Nitrofurantoin and 30 (17.14%) were multiresistant, that is, presented resistance to 3 or more classes of antibiotics. Of the 30 multiresistant isolates, resistance was obtained for the following classes of antibiotics: 20 (66.67%) were resistant to penicillins, quinolones/fluoroquinolones and sulfonamides; 3 (10%) were resistant to penicillins, quinolones/fluoroquinolones, aminoglycosides and sulfonamides; 2 (6.67%) were resistant to penicillins, quinolones/fluoroquinolones, aminoglycosides, sulfonamides and cephalosporins; 2 (6.67%) were resistant to penicillins, quinolones/fluoroquinolones and aminoglycosides; 1 (3.33%) was resistant to quinolones/fluoroquinolones, aminoglycosides and sulfonamides; 1 (3.33%) was resistant to penicillins, quinolones/fluoroquinolones, sulfonamides and cephalosporins; 1 (3.33%) was resistant to penicillins, quinolones/fluoroquinolones, aminoglycosides and cephalosporins. As observed, there are strains of P. mirabilis that present resistance to several antibiotics, which requires greater attention at the moment of choosing the treatment. In addition, it is important to raise public awareness about the misuse of antibiotics and consequently the possible origin of multiresistant strains.