Synthesis of Quinazoline Derivatives for Adenosine Kinase Inhibition

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The project consists in the development of three anilinoquinazoline synthetic derivatives (3-bromoanilinoquinazoline, 4-iodoanilinoquinazoline and 4-acetateanilinoquinazoline), by simple synthesis methods – ciclization, halogenation and eletrophilic aromatic substitution – with aplication on adenosine kinase (ADK) inhibition, which is linked with the prevention of many diseases, such as infarct, stroke and others.