Evaluation of the weight gain of hepatic gluconeogenesis markers in animals submitted to a hyperlipid diet supplemented with beet stems and leaves (​Beta vulgaris​ L.)

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Obesity is currently a worldwide epidemic related to excess adipose tissue, systemic inflammation, oxidative stress and development of insulin resistance, which characterizes type 2 diabetes mellitus. Foods rich in bioactive compounds have been studied to ameliorate oxidative stress, as well inflammation, which can be pro-oxidants and prepare the cells to resist the most severe stress conditions. One such food is beet (Beta vulgaris L.) and its by-products, which contains betalains and betaxanthines, phytochemicals with high antioxidant capacity. In this context, the purpose of this study was to evaluate the effect of stems and leaves of beet (Beta vulgaris L.) added to different high fat diets on metabolic parameters and hepatic function in experimental animals models. Forty swiss male mice were divided into five experimental groups: control diet (CT) with 10% of lipids, high-fat diet (HF) with 60% of lipids, high-fat diet supplemented with dehydrated beet leaves and stalks (HLFL) with 60% of lipids, high fat diet supplemented with serial extract of dehydrated beet leaves and stems (HLEX) with 60% of lipids and high-fat diet supplemented with freeze-dried beet leaves and stalks (HLLi) with 60% of lipids during 8 weeks. Mice fed with a high-fat supplemented with dehydrated and freeze-dried beet stalks and leaves diet during 8 weeks improved metabolic parameters and decreased PEPCK, suggesting an attenuation of gluconeogenesis in the liver.