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The Familial Hypercholesterolemia (FH) is the most common co-autosomal dominant inherited condition in man. It is mainly caused by mutations in the following three genes: the encoding: the receiver of low-density lipoprotein LDL-C (most common), or apolipoprotein B100 proprotein convertase subutilisina / kexina type 9 (PCSK-9). The resulting chron-ic elevations in LDL-C levels entail the development of early atherosclerotic cardiovascular disease.