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ANTI-DIABETIC PROPERTIES OF PITAYA (HYLOCEREUS POLYRHIZUS) IN ALOXAN-INDUCED DIABETIC MICE
Ana Paula Dionisio
Embrapa Agroindústria Tropical
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Crie um tópicoDiabetes is a metabolic disorder characterized by chronic hyperglycemia. There is a huge expenditure by the government, affected individuals and their families on diabetes treatment. Therefore, there is a growing interest in decreasing and controlling diabetes and its effects. There are a large number of studies suggesting dietary intake of polyphenols, especially flavonoids, associated with reduced risk of type 2 diabetes mellitus. It is known that the consumption of fruits and vegetables can reduce the risk of chronic degenerative diseases such as heart disease and type II diabetes, due to the presence of secondary metabolites such as carotenoids, phenolic compounds and betalains. Pitaya or dragon fruit has also been considered a rich source of bioactive compounds. The present study analyzed the hypoglycaemic effect and oxidative stress of pitaya (Hylocereus polyrhizus) in alloxan-induced diabetic mice. In the in vivo assays, the mice were divided into 5 groups (n=6): (a) Healthy group treated with water (0.2 mL of water/day/animal); (b) Diabetic mice treated with metformin at 200 mg/kg body weight diluted in water; (c) Untreated diabetic mice; (d) Diabetic mice treated with lyophilized pitaya at 200 mg/kg of body weight diluted in water; (e) Diabetic mice treated with lyophilized pitaya at 400 mg/kg of body weight diluted in water. The results shows that pitaya was able to reduce blood glucose (200 mg/kg); reduce cholesterol (200 and 400 mg/kg) and increase HDL-c (400 mg/kg). In the oxidative stress levels experiment, MDA (malondialdehyde) levels in the liver were significantly reduced in the groups treated with the lyophilized pulp, when compared to the other groups, suggesting lower lipid peroxidation.These results are possibly associated with constituents present in pitaya (Hylocereus polyrhizus), such as betalain, quercetin, flavonoids and prebiotics. However, more in vivo studies are needed to elucidate the bioactive(s) compound(s) responsable for these effects.
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Sandra Lira
Fomos motivados depois de ver a composição da pitaia...a composição dela nos levava a pensar que ela poderia ter um potencial hipoglicemiante. Obrigada pelo elogio!