Sensor eletroquímico para detecção do antidepressivo imipramina baseado em β-ciclodextrina e nanotubos carbono de paredes multiplas oxidado

Imipramine is a tricyclic antidepressant drug commonly prescribed for treatment of psychiatric patients suffering from different forms of depression [1]. The appropriated amount of imipramine intake is crucial to ensure the optimum therapeutic effects minimizing severe collateral effects and toxicity [1-3]. Therefore, the detection of imipramine is essential for its correct clinical applications. Herein, we report an electrochemical sensor based on cyclodextrin and oxidized multi-walled carbon nanotube (β-CD/MWCNTO) modified glassy carbon electrode for determination of imipramine in pharmaceutical samples. For imipramine detection, the β-CD/MWCNTO composite was previously modified with ferrocenecarboxylic acid (FeCO2H) in order to give a redox couple sensitive to imipramine. The proposed sensor was characterized by different techniques, including electrochemical impedance spectroscopy and cyclic voltammetry. The results show that imipramine determination with the proposed sensor occurs around 0.053 V in phosphate buffer pH 7.0. The imipramine determination in pharmaceutical samples was successfully performed using differential pulse voltammetry as measurement technique, with a linear range from 0.2 up to 10 µmol L-1 , sensibility of 0.096 μA L μmol-1 and a detection limit of 3.87 nmol L-1 . The proposed sensor was successfully applied in drug samples (tofranil) and the studies of addition and recovery of the analyte showed that the method shows a good accuracy with recovery percentage between 99 and 101% for the analyzed samples