Polímeros Molecularmente Impressos como fase sensora e atuadores no desenvolvimento de novos métodos de análise

Our research group has been working in the synthesis, optimization and application of conventional (MIPs) and magnetic (m-MIPs) molecularly imprinted polymers for various analytes, including: biotin; penicillin; folic acid; 1–chloro–2,4–dinitrobenzene; ametryn, dyes, between others. Aim at their use in different matrices, such as food, environment, and biological, and in the industrial quality control and others applications. For this, MIPs and hybrid nanomaterials (in a core@shell format on the surface of Fe3O4@SiO2magnetic nanoparticles - core) have been obtained through the thermal or photo-polymerization by bulk or precipitation methods using functional monomers, which are chosen by computational simulations; cross-linking agent, radical initiator and porogenic solvent [1]. In all cases, the morphological, topological and physics characteristics of these materials have been investigated by scanning (SEM) and transmission (TEM) electron microscopies, Fourier transform infrared (FTIR), N2adsorption/desorption by BET isotherms, vibrating sample magnetometry (VSM) to m-MIPs, TGA, RMN and XRD techniques. The physic-chemical characterization, such as adsorption capacities, imprinting factor and selectivity of these materials have been investigated and compared with the respective NIPs and m-NIPs, which are control polymers without selective cavity. After, all characterizations, some of these selective nanomaterials have been evaluated like modifiers of carbon paste (CPE), magnetic graphite composite (m-GCE) electrodes and optical fibers, aiming at develop biomimetic sensors with electrochemical and optical transduction; and evaluated like actuators in pseudo-immunoassays and more recently, in lateral flow systems. In this keynote, some successful examples will be present.