A molecular dynamics approach to spermine and spermidine SI-PPCs interactions with heparin and DNA

Cancer chemotherapy has been the focus of many researchers mainly due to the efforts to develop a medicine which has even or better efficiency than cisplatin and its analogues and also reduced side effects;
The SI-PPCs have been tested experimentally and demonstrated as good alternatives to those current medications for certain branches of cancer, however more pieces of research have to be carried out;
The noncovalent interactions between a drug and DNA (Or also heparan sulphate) opened a novel path in drug development promising lower side effects and comparable interactions as cisplatin analo