3H-pyrrolo[2,3-c]quinoline is a tricyclic system rare between natural products. The first example reported was Marinoquinoline A, isolated from the gliding bacterium Ohtaekwangia kribbensis together with the novel marinoquinolines B-F. These compounds have demonstrated activity as acetylcholinesterase inhibitor, antibiotic activity, antitumoral and antiprotozoatic. In view of the pharmacological potential of marinoquinolines, the present work describes the moldular synthesis of
novel marinoquinolines. Pyrroloanilines intermediates were synthesized by Suzuki-Miyaura cross-couplings followed by Pictet-Spengler cyclizations to obtain the desired pyridine-marinoquinoline in good overall yields.