On conformational isomerism of a Ru(II) complex and potential anticancer activities to its derivatives.

Favoritar este trabalho
Como citar esse trabalho?
Detalhes
  • Tipo de apresentação: Exposição de Pôster
  • Eixo temático: Química Inorgânica - INO
  • Palavras chaves: ruthenium complexes; Fluorescent complexes; 1,4-Bis(diphenylphosphino)butane; Isomerism;
  • 1 Universidade Federal de São Carlos
  • 2 Universidade de São Paulo
  • 3 Universidade Federal de São Carlos/Universidade Federal de Goiás

On conformational isomerism of a Ru(II) complex and potential anticancer activities to its derivatives.

Leticia Pires de Oliveira

Universidade Federal de São Carlos

Resumo
   Ruthenium complexes have been excelled for demonstrating potential activity against cancer and against infectious diseases.1 Thus, one approach in the field of cancer is related to the target of the agent on study. In this case, should be good to know how the drug, or the potential drug, interacts with the target, by which mecanism, and to know if the compound acts inside, or outside the cell, for instance. Trying to answer some of these questions, in this work new ruthenium complexes with fluorescence properties, were synthesized, and for this a pyrene(py) derivative, a quimiosensor specie, was used as ligand.2 The new ruthenium complexes have in their coordination sphere, basically, the 1,4-bis(diphenylphosphino)butane, 2-(1-pyrenil)1H-imidazo[4,5-f][1,10]-phenantroline (pyphen), using the chloride complex as precursor (see Fig. 1). To complete the coordination sphere of the metal, mercapto ligands were used (Complex A2, Fig. 2). It is interesting to mention that the 31P{1H} NMR spectrum of the precursor showed a complex pattern, different of the expected for a AX system, suggesting that more than one specie was in solution, according Fig. 3. Also, the spectra of the complex are a little different, depending of the solvent used in the experiment. The hypothesis of the presence of more than one compound in solution was discarded by cyclic voltammetry experiments, where only one oxidation process, Ru(II)→Ru(III), was observed, which was supported by mass spectra data. In order to evaluated the presence of possible isomers of the precursor, in solution, NMR spectra, in solid state, were undertaken, and the results suggest the presence of conformational isomers, which was confirmed by 31P{1H} experiments, where at least five signals were observed. Additionally, worth it to mention that the reaction of the precursor with the mercapto ligand (complex A2), only one complex was obtained, again, suggesting that in the precursor solution only one specie was present. Worth it to mention that, the obtained complexes are fluorescent, and can be used as probe to study the mechanism of their interaction with the cancer cells. 1HONORATO, J. et al. Inorg. Chem. Front. v. 6, p. 376-390, 2019. 2RANIK,B.K.; JOHN, S.A. J. Hazard. Mater. v. 343, p. 98-106, 2018.
Questões (2 tópicos)

Compartilhe suas ideias ou dúvidas com os autores!

Sabia que o maior estímulo no desenvolvimento científico e cultural é a curiosidade? Deixe seus questionamentos ou sugestões para o autor!

Faça login para interagir

Tem uma dúvida ou sugestão? Compartilhe seu feedback com os autores!

Leticia Pires de Oliveira

Autor
Agradeço pelas congratulações, Profª Shirley! Foi uma honra poder apresentar este trabalho na reunião anual da SBQ. O composto A2 foi sintetizado tanto para investigação de sua localização com microscopia confocal, assim como para ser avaliado em sistemas biológicos, tal como seu similar citado no trabalho, o complexo A8. Agradeço! Leticia.

Leticia Pires de Oliveira

Autor
Obrigada Profª Shirley! Espero logo ter mais resultados a compartilhar!