Coriandrum sativum L. (Apiaceae), popularly known as coriander (“coentro” in Brazil) and for presenting a strongly aromatic fragrancy, and exotic slightly sweet flavor, favoring it use as a condiment in the cuisine of different parts of the world. Its aromatic, nutritional and therapeutic properties are due to the chemical composition of its different plant parts¹. However, the most studied part and, therefore, with greater indications are its fruits/seeds. Studies highlight the antimicrobial, antioxidant, hypoglycemic, hypolipidemic, anxiolytic, analgesic, anti-inflammatory, anticonvulsant and anticancer potential of coriander². Although there are reports about its antitumor activity³, especially of its seeds, against breast and prostate cancer cells, so far, no study has evaluated the antitumor potential of its leaves against the human neuroblastoma lineage. Thus, herein the hydroethanolic extract from all parts of coriander (CSHE) were subjected to UPLC/DAD-ESI/HRMS/MS analysis and evaluation of its cytotoxicity and cell death mechanism against neuroblastoma cell line of bone marrow (SH-SY5Y). The IC₅₀ value of CSHE against SH-SY5Y cell line was defined as 20 mg/mL. In addition, the annexin V/propidium iodide assay suggested apoptosis as cell death mechanism. Those results can be explained by the chemical investigation, especially for isocoumarins (coriandrin, dihydrocoriandrin and coriandrone) purines (adenin and adenosine), aminoacid (tryptophan), flavonoids (rutin and apigenin), phospholipids (PAF C-16 and LysoPC - 16:0) and acylglicerol (monolinolenin) found at this extract. In conclusion, further experiments are necessary to determine whether those bioactive compounds act in synergism or an isolated compound could be the main responsible for the antitumoral activity.