Anticancer Potential of Marine Microorganisms Isolated from the Sediment of Queimada Grande Island, São Paulo, Brazil

Vol 9, 2023 - 167438
Poster
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Abstract

This study explored Queimada Grande Island's marine microorganisms for anticancer compounds. Eight extracts inhibited HCT-116 cell growth by 75% at 50 μg/mL. BRB-640 extracts obtained in liquid and solid media showed IC50 values of 1.03 µg/mL and 3.38 µg/mL, respectively. Culture media vastly affected BRB-640 cytotoxicity, with SCB culture yielding more potent extracts. This research highlights marine microorganisms' anticancer potential and the role of culture conditions in extract bioactivity.

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Institutions
  • 1 Universidade Federal de São Paulo - Instituto do Mar
Track
  • 2. Biological and Pharmacological Activity of Natural Products
Keywords
Bioprospecting; marine natural products; cytotoxicity; Actinobactéria; OSMAC