Virtual Screening in the Search for Alkaloids as New Inhibitors of Staphylococcus aureus Dihydrofolate Reductase

Vol 9, 2023 - 166847
Poster
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Abstract

A QSAR model was built with banks of alkaloid-like chemical structures following OECD guidelines. The model was able to select the alkaloid ramiflorine A, which has been described in the literature as an inhibitor of Staphylococcus aureus dihydrofolate reductase (SaDHFR).

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Institutions
  • 1 Universidade Federal de Sergipe
  • 2 Federal University of Sergipe
Track
  • 2. Biological and Pharmacological Activity of Natural Products
Keywords
in silico studies; QSAR; Natural products; SaDHFR