Synthesis of new analogues of marinoquinolines and their biological activity against malaria

Vol. 1, 2019 - 107647
Poster only
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Abstract

Natural marinoquinolines were extracted from sea bacteria, and biological assays have indicated moderate activity against malaria (Plasmodium falciparum K1) ranging from 1.7 to 15 micromolar. Based on these studies, our work aimed at the total synthesis of several unnatural marinoquinolines possessing diverse substitution pattern and to explore their pharmacological activity as novel antimalarial compounds. Most of the new marinoquinolines synthesized in the present study have demonstrated antimalarial activity at the micromolar and nanomolar scale.

Institutions
  • 1 Institute of Chemistry / State University of Campinas
  • 2 São Carlos Institute of Physics / University of São Paulo
Track
  • 1. Strategies in Drug Design
Keywords
Synthesis
marinoquinolines
antimalarials