qNMR in Natural Products: Practical approaches

Vol 2, 2023 - 162099
Invited Lecturer
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Resumo

Until recently, it was common to observe applications of qNMR (quantitative nuclear magnetic resonance) in samples from the area of Natural Products without the same rigor as analytical works, particularly regarding validation. However, even though new approaches have emerged with the expression of uncertainties involved in the analyses [1-2], some practical details such as sampling plants, extracts preparation and NMR parameters adjustment need to be carefully evaluated. In this sense, this lecture will use the study of qNMR in extracts of Vernonia rubricaulis, guided from previous metabolomic studies, for investigating the compound potentially responsible for the toxicity of this plant in cattle, in order to explore the sample and experimental factors that impact the results.

[1] Crocoli et al. Natural Products Sciences 27(2): 128-133, 2021.
[2] Owczarek et al. Talanta 192: 263-269, 2019.

CNPq, FUNDECT, CAPES, UFMS

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Instituições
  • 1 Universidade Federal de Mato Grosso do Sul
Palavras-chave
Vernonia rubricaulis; plant extract