LOWER DIETARY ANTIOXIDANT CAPACITY IS ASSOCIATED WITH HIGHER SYSTOLIC BLOOD PRESSURE IN NON-EUTROPHIC PATIENTS WITH PSORIASIS

Psoriasis is a chronic, inflammatory disease that favours cardiometabolic repercussions and compromises the cellular antioxidant system. This study aimed to evaluate the dietary antioxidant profile in individuals with psoriasis and its association with nutritional status and cardiometabolic parameters. The study was previously submitted to and approved by the Research Ethics Committee of the Lauro Wanderley University Hospital, with a favorable opinion for its execution. This cross-sectional study involved 159 patients with psoriasis, recruited from a university hospital in Northeastern Brazil. Usual food intake was assessed using the 24-hour Dietary Recall method on three nonconsecutive days, conducted by previously trained researchers. The interviews followed the multiple-step method proposed by Moshfegh et al. (2008). The total antioxidant capacity of the diet (TACd) was estimated using a database previously published by Carlsen et al. (2010), supplemented by additional literature that also used the Ferric Reducing Antioxidant Power method for determining TACd. Nutritional status was assessed by calculating the Body Mass Index, classified according to the World Health Organization, and patients were stratified into Eutrophic and non-eutrophic groups. Biochemical parameters were obtained from analyses previously carried out at the HULW Clinical Analysis Laboratory. Blood pressure was measured using calibrated mercury sphygmomanometers. Statistical analysis included the Mann-Whitney U test, Pearson's chi-square test, adjusted partial correlations (for age, sex, and energy intake), and bootstrapping procedures. The Non-eutrophic group exhibited significantly higher systolic blood pressure, diastolic blood pressure, fasting glucose, triglycerides, alanine aminotransferase, total protein, and vitamin B12 levels (p < 0.05), along with lower HDL-c levels (p < 0.001). Mean TACd did not differ between Eutrophic (2.5 ± 3.8 mmol/day) and Noneutrophic groups (2.9 ± 4.7 mmol/day; p = 0.993), nor did it correlate with individual antioxidant nutrients. This result indicates that, despite a compromised metabolic profile, the non-eutrophic group had the same antioxidant intake as the eutrophic group. There was no correlation between the isolated consumption of antioxidant nutrients and TACd. These findings corroborate Carlsen et al. (2010) data, suggesting that the antioxidant diet effect results from the combined action and interaction among multiple foods consumed, not from isolated nutrients alone. However, when stratified by median TACd (0.303 mmol/day), non-eutrophic individuals with lower TACd demonstrated significantly higher Systolic Blood Pressure when compared to those with higher TACd (138.2 ± 19.8 mmHg vs. 128.7 ± 14.3 mmHg; p < 0.05). In conclusion, dietary antioxidant capacity occurs independently of nutritional status; nonetheless, lower TACd is associated with higher systolic blood pressure in non-eutrophic patients with psoriasis, highlighting the role of antioxidant-rich diets in mitigating cardiovascular risk in the psoriasis population.