MODERATE PHYSICAL EXERCISE IMPROVES CARDIOTOXICITY IN RATS TREATED WITH CISPLATIN

Chronic use of chemotherapy drugs can cause cardiotoxicity. Cardiac events may include mild changes in blood pressure, thrombosis, electrocardiographic changes, arrhythmias, myocarditis, cardiomyopathy, heart failure, and congestive heart failure. Cisplatin is a prescribed chemotherapy drug for human cancers. Furthermore, acute and cumulative treatment with cisplatin induces cardiotoxicity, such limiting factors for cisplatin therapy. To mitigate the adverse effects caused by cisplatin, physical exercise can also be a non-pharmacological intervention.