REACTIVE OXYGEN SPECIES INFLUENCE ON PRO-INFLAMMATORY CYTOKINES EXPRESSION DURING THE EPILEPTOGENESIS.

Epilepsy is a neurological disorder that consists of more than 40 clinical syndromes in that the brain function is characterized by a predisposition to generate recurrent seizures that can carry neurobiological, cognitive, psychological and social consequences, amongst them, employment lost, hospital visits and the overall disruption of life quality. The most prevalent form of the disease is Temporal Lobe Epilepsy (TLE), which corresponds to ~40% of the cases, of which ⅓ are refractory to the current pharmacological treatments. Reactive oxygen species (ROS) facilitate this process or epileptogenesis together with neuroinflammation. Thus, we hypothesized that changes in ROS disbalance may play a key role in the pro-inflammatory cytokines expression on TLE.