MURF1 INHIBITION PREVENTS EARLY DISUSE-INDUCED DIAPHRAGMATIC DYSFUNCTION AND ATROPHY

In clinical conditions such as diaphragm paralysis or mechanical ventilation, disuse-induced diaphragmatic dysfunction (DIDD) is a prevalent complication linked to higher risks of patient respiratory failure, mortality, and healthcare costs. The up-regulation of Muscle RING-finger protein-1 (MuRF1), an E3-ligase involved in controlling skeletal muscle mass, function, and energy metabolism, has been reported in the early onset of DIDD.