Long-Term Modulation of Vascular Reactivity by Testosterone and Aldosterone in Orchiectomized Wistar Rats Treated with Spironolactone

Testosterone, a vasoactive hormone, exerts its effect via genomic and non-genomic pathways and has been shown to exhibit endothelium-dependent vasodilation in acute scenarios. Nevertheless, the impact of testosterone on the long-term regulation of vascular tone has not been well elucidated.